ELK Biotechnology Glutamate Receptor 1 rabbit pAb

Glutamate Receptor 1 rabbit pAb

제품 개요

Glutamate Receptor 1 (GluA1)는 포유류 뇌에서 주요 흥분성 신경전달물질 수용체로, 다양한 신경생리학적 과정에서 활성화됩니다. 이 항체는 GluA1 단백질의 특정 합성 펩타이드(AA 773–823)에 대해 제작된 rabbit polyclonal antibody입니다.

주요 정보

세포 내 위치

• Cell membrane; multi-pass membrane protein
• Endoplasmic reticulum membrane; multi-pass membrane protein
• Cell junction, synapse, postsynaptic cell membrane; multi-pass membrane protein
• Postsynaptic density membrane; multi-pass membrane protein
• Cell projection (dendrite, dendritic spine)
• Early endosome membrane; recycling endosome membrane
• Presynapse; synapse
• Interaction with CACNG2, CNIH2, and CNIH3 promotes cell surface expression
• Colocalizes with PDLIM4 in early endosomes
• Displays somatodendritic localization and is excluded from axons in neurons (By similarity)
• Localized to cone photoreceptor pedicles (By similarity)

Background

Glutamate receptors are predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in various normal neurophysiologic processes. These receptors are heteromeric protein complexes with multiple subunits forming ligand-gated ion channels. Glutamate receptors are classified based on activation by different pharmacologic agonists. This gene belongs to the AMPA receptor family (alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate). Alternatively spliced transcript variants encoding different isoforms have been identified (RefSeq, Jul 2008).