
ELK Biotechnology CIB1 rabbit pAb
CIB1 단백질을 인식하는 토끼 폴리클로날 항체로, WB와 ELISA에 적합합니다. 인간 유래 합성 펩타이드(AA 70-150)를 면역원으로 제작되었으며, 세포막 및 세포골격 등 다양한 세포 위치에서 발현을 탐지할 수 있습니다. 장기 보관이 가능한 고품질 항체입니다.
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제품명
CIB1 rabbit pAb
제품 개요
CIB1(Calcium and integrin-binding protein 1)은 EF-hand 도메인을 가진 칼슘 결합 단백질로, 다양한 단백질과 상호작용하며 세포 생존 및 증식에 관여합니다. 본 항체는 인간 CIB1 유래 펩타이드를 면역원으로 제작된 토끼 폴리클로날 항체로, WB 및 ELISA 실험에 적합합니다.
주요 정보
| 항목 | 내용 |
|---|---|
| Product name | CIB1 rabbit pAb |
| Alternative Names | Calcium and integrin-binding protein 1 (CIB; CIBP; Calmyrin; DNA-PKcs-interacting protein; Kinase-interacting protein; KIP; SNK-interacting protein 2-28; SIP2-28) |
| Applications | WB; ELISA |
| Recommended Dilutions | WB: 1:1000–2000 ELISA: 1:5000–20000 |
| Immunogen | Synthesized peptide derived from human CIB1 (AA 70–150) |
| Host | Rabbit |
| Storage | -20°C, 1 year |
| Clonality | Polyclonal |
| Isotype | IgG |
| Concentration | 1 mg/ml |
| Gene ID (Human) | 10519 |
| Human Swiss-Prot No. | Q99828 |
| Species Reactivity | Human; Rat; Mouse |
세포 내 위치
Membrane; Lipid-anchor; Cell membrane (sarcolemma, apical membrane); Cell projection (ruffle membrane, filopodium tip, growth cone, lamellipodium); Cytoplasm; Cytoskeleton (microtubule organizing center, centrosome); Perinuclear region; Nucleus; Neuron projection; Perikaryon.
Colocalized with PPP3R1 at the cell membrane of cardiomyocytes in hypertrophic heart (By similarity).
Colocalized with NBR1 in the perinuclear region and with TAS1R2 in apical regions of taste receptor cells.
Colocalized with RAC3 and PAK1 within membrane ruffles during cell spreading upon readhesion to fibrinogen.
Background
This gene encodes a member of the EF-hand domain-containing calcium-binding superfamily. The encoded protein interacts with multiple partners, including platelet integrin αIIbβ3, DNA-dependent protein kinase, presenilin-2, focal adhesion kinase, p21-activated kinase, and protein kinase D. It may play a role in cell survival and proliferation and is associated with several disease states, including cancer and Alzheimer’s disease. Alternative splicing results in multiple transcript variants.
[Provided by RefSeq, Apr 2013]
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