Thermo Fisher Scientific CYP1A1 Polyclonal Antibody
CYP1A1 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P) 분석에 적합합니다. Human과 Mouse 시료에 반응하며, 약물 대사 관련 연구에 활용 가능합니다. 2 mg/mL 농도의 액상 제품으로 안정적인 장기 보관이 가능합니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:10–1:50 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | KLH-conjugated synthetic peptide corresponding to amino acids 377–405 of the C-terminal region of human CYP1A1 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 2 mg/mL |
| Purification | Size-exclusion chromatography, dialysis, ammonium sulfate precipitation |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C for short term; for long-term storage, store at -20°C. Avoid freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2088694 |
Product Specific Information
This antibody is predicted to react with non-human primate species based on sequence homology.
Target Information
The CYP1A1 gene encodes a member of the cytochrome P450 superfamily of enzymes. These monooxygenases catalyze various reactions involved in drug metabolism and the synthesis of cholesterol, steroids, and other lipids. The protein localizes to the endoplasmic reticulum, and its expression is induced by certain polycyclic aromatic hydrocarbons (PAHs), including those found in cigarette smoke. Although the enzyme’s endogenous substrate is unknown, it can metabolize some PAHs into carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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