Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI9C1), TrueMAB
Beta-catenin 단백질을 인식하는 마우스 모노클로날 항체로, Western blot, IHC, ICC/IF에 사용 가능. 다양한 종(Human, Mouse, Rat, Dog)에 반응하며, 세포 성장 및 접착 연구에 적합. Lyophilized 형태로 제공되며, 고순도 affinity chromatography 정제.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:200–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC-P) | 1:150 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Dog, Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI9C1 |
| Immunogen | Full length human recombinant protein of human CTNNB1 produced in HEK293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin, linking the adhesion complex to the actin cytoskeleton. Beta-catenin also associates with the adenomatous polyposis coli protein and microtubules, participating in signaling pathways including Wnt/Wingless.
It plays a key role in morphogenesis and is expressed in various hair follicle cell types. Pathologically, beta-catenin is implicated in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of cyclin D and c-myc, which drive cell proliferation and tumorigenesis.
For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.
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