Thermo Fisher Scientific Beta-catenin Monoclonal Antibody (OTI9C1), TrueMAB

Applications and Tested Dilution

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to obtain a final antibody concentration of about 1 mg/mL.
For conjugation experiments using this carrier-free antibody, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).

Target Information

Beta-catenin is an adherens junction (AJ) protein involved in cell-cell adhesion and epithelial layer maintenance. It interacts with E-cadherin and alpha-catenin, linking the adhesion complex to the actin cytoskeleton. Beta-catenin also associates with the adenomatous polyposis coli protein and microtubules, participating in signaling pathways including Wnt/Wingless.
It plays a key role in morphogenesis and is expressed in various hair follicle cell types. Pathologically, beta-catenin is implicated in pilomatrixoma, medulloblastoma, colorectal cancer, ovarian cancer, and other solid tumors.
In the nucleus, beta-catenin co-activates Lef/Tcf transcription factors, promoting expression of cyclin D and c-myc, which drive cell proliferation and tumorigenesis.

For Research Use Only.
Not for use in diagnostic procedures or resale without authorization.