Thermo Fisher Scientific beta-2 Adrenergic Receptor Recombinant Mouse Monoclonal Antibody (R11/E1)
인간 beta-2 아드레날린 수용체를 인식하는 마우스 재조합 단클론 항체입니다. Western blot, ICC/IF, Flow cytometry, IP에 사용 가능합니다. 고순도 Protein A 정제, 1 mg/mL 농도로 제공됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | Assay-dependent | - |
| Flow Cytometry (Flow) | Assay-dependent | - |
| Immunoprecipitation (IP) | Assay-dependent | - |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | R11/E1 |
| Immunogen | This antibody was raised by immunizing mice with beta-2 adrenergic receptor. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A |
| Storage buffer | PBS |
| Contains | 0.02% ProClin 300 |
| Storage conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping conditions | Wet ice |
| RRID | AB_3074744 |
Product Specific Information
Specificity: R11/E1 antibody recognizes human beta-2 adrenergic receptor.
Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through G proteins.
The beta-2-adrenergic receptor binds adrenaline with far greater affinity than noradrenaline.
Target Information
Adrenergic receptors (ARs) are members of the 7-transmembrane domain G-protein-coupled receptor superfamily that bind endogenous catecholamines epinephrine and norepinephrine.
Pharmacological, structural, and molecular cloning data indicate significant heterogeneity within this receptor family.
Nine receptor subtypes have been identified so far, including:
- Three alpha-1 AR subtypes (1A/D, 1B, 1C)
- Three alpha-2 ARs (2A, 2B, 2C)
- Three beta AR subtypes (1, 2, 3)
ARs participate in the onset or maintenance of several disease states including hypertension, cardiac dysfunction (congestive heart failure, ischemia, arrhythmias), diabetes, glaucoma, depression, and impotence.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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