Thermo Fisher Scientific RHOH Monoclonal Antibody (OTI9F4), TrueMAB

Applications

• Western Blot (WB): Tested dilution 1:2,000

Product Specifications

Product Specific Information

For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (e.g., Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

The Rho subfamily of small GTP-binding proteins mediates key cellular functions such as actin reorganization, adhesion, cytokinesis, and motility.
RhoH (also known as TTF or ARHH) is distinct from other small G proteins, being expressed only in hematopoietic cells.
RhoH mutations and translocations are associated with primary lymphoma cells, and expression has been noted in activated neutrophils.
Unlike most small GTPases, RhoH is GTPase-deficient and remains in a GTP-bound activated state, potentially influencing T-cell differentiation and cytoskeletal organization.
The RhoH/TTF (ARHH) gene maps to chromosome 4p13 and encodes a 191-amino-acid polypeptide.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.