Thermo Fisher Scientific AXIN2 Polyclonal Antibody
AXIN2 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 IHC(P)에서 검증됨. 인간, 마우스, 랫트 시료에 반응. 합성 펩타이드 항원을 사용하여 제작되었으며, 액상 형태로 제공. 연구용으로만 사용 가능.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:200 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host/Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthesized peptide derived from human AXIN2 (Accession Q9Y2T1), corresponding to amino acid residues G41–G91 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.4, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | –20°C |
| Shipping conditions | Wet ice |
| RRID | AB_2852019 |
Product Specific Information
Antibody detects endogenous levels of total AXIN2.
Target Information
The Axin-related protein AXIN2 plays a key role in regulating the stability of beta-catenin in the Wnt signaling pathway. In mouse, conductin (the homolog of AXIN2) forms a multiprotein complex with APC, beta-catenin, and glycogen synthase kinase 3-beta, leading to beta-catenin degradation. Deregulation of beta-catenin is linked to several malignancies. The AXIN2 gene is mapped to 17q23–q24, a region frequently showing loss of heterozygosity in breast cancer, neuroblastoma, and other tumors. Mutations in AXIN2 are associated with colorectal cancer with defective mismatch repair.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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