Thermo Fisher Scientific CLASP2 Monoclonal Antibody (KT68)
CLASP2 단백질을 특이적으로 인식하는 Rat 모노클론 항체(KT68)로, WB 및 ICC/IF에 적합합니다. 인간, 생쥐, 랫트 시료에서 반응하며 단백질 안정화 연구에 활용됩니다. 단기 4°C, 장기 -20°C 보관 권장.
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Thermo Fisher Scientific CLASP2 Monoclonal Antibody (KT68)
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rat / IgG2b |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KT68 |
| Immunogen | Clone KT68 was generated from a GST fusion protein containing the N-terminus of mouse CLASP2. This sequence is highly conserved in human and rat CLASP2, and has low homology to CLASP1. |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | ~1.0 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2942690 |
Product Specific Information
This antibody detects a 160 kDa* doublet corresponding to the molecular mass of CLASP2 on SDS-PAGE immunoblots of human HeLa, mouse brain, and rat PC12 cells.
The antibody also detects CLASP2 by immunocytochemistry in HeLa and A431 cells.
Target Information
CLASP2 is a microtubule plus-end tracking protein that promotes the stabilization of dynamic microtubules.
It is required for the polarization of cytoplasmic microtubule arrays in migrating cells toward the leading edge.
CLASP2 may act at the cell cortex to enhance rescue frequency of depolymerizing microtubules by attaching their plus-ends to cortical platforms composed of ERC1 and PHLDB2.
This cortical microtubule stabilizing activity is regulated by phosphatidylinositol 3-kinase signaling.
CLASP2 also performs a similar stabilizing function at the kinetochore, essential for bipolar alignment of chromosomes on the mitotic spindle.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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