Thermo Fisher Scientific Phospho-HBP1 (Ser402) Polyclonal Antibody
HBP1 단백질의 Ser402 인산화 부위를 인식하는 rabbit polyclonal 항체입니다. Western blot에 적합하며, 인간, 마우스, 랫트 시료에서 반응합니다. 항원 친화 크로마토그래피로 정제되었으며, 고순도(>95%)를 보장합니다. 연구용으로만 사용 가능합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:1,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic phosphopeptide derived from human HBP1 around the phosphorylation site of Serine 402 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 15 mM sodium azide |
| Storage Conditions | Store at 4°C (short term). For long-term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2553748 |
Product Specific Information
- Detects endogenous HBP1 protein at molecular weights of 58 kDa and 80 kDa.
- Purity: >95% by SDS-PAGE.
Target Information
HMG-box protein-1 (HBP1) is a transcription factor belonging to the HMG family, characterized by a conserved high mobility group (HMG) 1 box that mediates DNA binding.
HBP1 interacts with tumor suppressor proteins Rb and p130, initiating cell cycle arrest. This arrest is required for terminal cell differentiation, which is followed by the expression of tissue-specific genes.
Continued HBP1 activity can suppress tissue-specific gene expression by associating with MyoD proteins. In muscle differentiation, the MyoD family (Myf5, MyoD, myogenin) induces expression of cell-type specific proteins and contributes to phenotype development. Proper differentiation progression depends on decreased HBP1 activity and activation of MyoD-induced transcription.
For Research Use Only.
Not for use in diagnostic procedures.
Not for resale without express authorization.
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