Thermo Fisher Scientific KAL1 Monoclonal Antibody (OTI5E10), TrueMAB
인간 KAL1 단백질을 인식하는 마우스 단클론 항체로, IHC(P) 적용 가능. TrueMAB 형식의 고순도 항체이며, 동결건조 형태로 제공. 연구용으로만 사용되며 Kallmann 증후군 관련 연구에 적합.
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Thermo Fisher Scientific KAL1 Monoclonal Antibody (OTI5E10), TrueMAB
Applications
- Immunohistochemistry (Paraffin) (IHC (P))
Tested Dilution: 1:500
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI5E10 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 129–373 of human KAL1 produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
KAL1 (Anosmin-1) is an extracellular matrix-associated glycosylated protein linked to Kallmann Syndrome (KS), an X-linked genetic disorder characterized by anosmia and delayed puberty due to abnormal olfactory bulb development and disrupted migration of gonadotropin-releasing hormone neurons.
Anosmin-1 binds FGFR1 through its N-terminal cysteine-rich, whey-acidic protein-like, and first FnIII domains, interacting with FGFR1’s D2 and D3 ectodomains. It modulates FGFR1 signaling and influences FGF2-FGFR1-heparin complex formation and activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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