Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody, MaxPab

Thermo Fisher Scientific TNFAIP6 Polyclonal Antibody, MaxPab

Applications

• Western Blot (WB): 1:500–1:1,000

Product Specifications

Product Specific Information

Sequence of this protein is as follows:
MIILIYLFLL LWEDTQGWGF KDGIFHNSIW LERAAGVYHR EARSGKYKLT YAEAKAVCEF EGGHLATYKQ LEAARKIGFH VCAAGWMAKG RVGYPIVKPG PNCGFGKTGI IDYGIRLNRS ERWDAYCYNP HAKECGGVFT DPKQIFKSPG FPNEYEDNQI CYWHIRLKYG QRIHLSFLDF DLEDDPGCLA DYVEIYDSYD DVHGFVGRYC GDELPDDIIS TGNVMTLKFL SDASVTAGGF QIKYVAMDPV SKSSQGKNTS TTSTGNKNFL AGRFSHL

Target Information

The TSG6 gene is transcribed in normal fibroblasts and activated by binding of cytokines TNF alpha and IL-1 at AP-1 and NF-IL6 sites in its promoter.
TSG-6 is a glycoprotein and a member of the hyaluronan-binding protein family, which includes cartilage link protein, proteoglycan core protein, and the adhesion receptor CD44.
TSG-6 is highly homologous to CD44, particularly in the hyaluronic acid-binding domain.
It is found in TNF-treated cells and its expression is rapidly activated by TNF alpha, IL-1, and lipopolysaccharide in normal fibroblasts, peripheral blood mononuclear cells, synovial cells, and chondrocytes.
The presence of TSG-6 in synovial fluid suggests a possible role in rheumatoid arthritis.
TSG-6 forms a stable complex with components of the serine protease inhibitor inter-alpha-inhibitor (IαI).
It potentiates the inhibitory effect of IαI on the protease activity of plasmin.
Through their cooperative inhibitory effect on plasmin, TSG-6 and IαI can modulate the protease network and thus inhibit inflammation.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.