Thermo Fisher Scientific MMP2 Monoclonal Antibody (MMP2/2C1-1D12)

Applications and Tested Dilutions

Product Specifications

Product Specific Information

MA1-779 contains 100 µg of in vitro produced, Protein A purified antibody (1 mg/mL) in PBS containing 1 mg/mL BSA and 0.05% sodium azide.
MA1-779 has been successfully used in Western blot applications. By Western blot, MA1-779 detects a ~66 kDa band representing purified recombinant human MMP-2.
The MA1-779 immunogen is activated rhMMP-2.

Target Information

Matrix metalloproteinases (MMPs) are proteolytic enzymes capable of degrading connective tissue components. They share a common activation mechanism, a conserved amino acid sequence in the metal-binding active site region, and are inhibited by tissue inhibitors of metalloproteinases (TIMPs).
MMPs and TIMPs play significant roles in regulating angiogenesis. MMP2 is synthesized as a 631-amino acid proenzyme, activated by cleavage of the first 80 amino acids, and contains propeptide, catalytic, and hemopexin domains.
MMPs can degrade extracellular matrix components including collagens, fibronectin, laminin, and basement membrane glycoproteins. Structurally, they possess a signal peptide, propeptide, and catalytic domain with a conserved zinc-binding site.
Functionally, MMP2 is involved in tissue remodeling. Mutations in the MMP2 gene are associated with Winchester syndrome and Nodulosis-Arthropathy-Osteolysis (NAO) syndrome. Two transcript variants encoding different isoforms of MMP2 have been identified.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.