Thermo Fisher Scientific SHARPIN Monoclonal Antibody (OTI2B1), TrueMAB
SHARPIN 단백질을 표적으로 하는 Thermo Fisher Scientific의 단클론 항체로, Western blot에 최적화되어 있습니다. Human 시료에 반응하며, IgG2a 아이소타입의 Mouse 유래 항체입니다. LUBAC 복합체 연구 및 NF-kappa-B 신호전달 연구에 적합합니다.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific SHARPIN Monoclonal Antibody (OTI2B1), TrueMAB
Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI2B1 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–326 of human SHARPIN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
SHARPIN is a component of the LUBAC complex, which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates. It plays a key role in NF-kappa-B activation and inflammation regulation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1, participating in activation of canonical NF-kappa-B and JNK signaling pathways.
Linear ubiquitination mediated by LUBAC interferes with TNF-induced cell death, thereby preventing inflammation.
LUBAC is proposed to be recruited to the TNF-R1 signaling complex after polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3.
Together with FAM105B (otulin), the LUBAC complex regulates canonical Wnt signaling during angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.