Thermo Fisher Scientific SHARPIN Monoclonal Antibody (OTI1D11), TrueMAB
인간 SHARPIN 단백질(aa 1-326)을 인식하는 Mouse IgG2a 단일클론 항체입니다. Western blot에 최적화되어 있으며, LUBAC 복합체 관련 NF-κB 및 염증 조절 연구에 적합합니다. 무보존제, 동결건조 형태로 제공되며 -20°C에서 보관합니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1D11 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–326 of human SHARPIN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SHARPIN is a component of the LUBAC complex, which conjugates linear polyubiquitin chains in a head-to-tail manner to substrates, playing a key role in NF-κB activation and inflammation regulation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1, activating canonical NF-κB and JNK signaling pathways.
This process interferes with TNF-induced cell death, preventing inflammation.
LUBAC is recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3, stabilizing the complex.
Together with FAM105B/otulin, LUBAC regulates canonical Wnt signaling during angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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