Thermo Fisher Scientific SHARPIN Monoclonal Antibody (OTI1F4), TrueMAB
Human SHARPIN 단백질(aa 1-326)을 항원으로 제작된 Mouse IgG1 단클론 항체. Western blot에 적합하며, NF-κB 활성 및 염증 조절 연구에 유용. 동결건조 형태로 제공되며 PBS, trehalose buffer에 보관. 연구용으로만 사용 가능.
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Applications
- Western Blot (WB): Tested dilution 1:500–1:2,000
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI1F4 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 1–326 of human SHARPIN produced in E. coli |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | –20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to achieve a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step using Zeba Spin Desalting Columns (7K MWCO, 0.5 mL, Product #89882).
Target Information
SHARPIN is a component of the LUBAC complex, which conjugates linear polyubiquitin chains to substrates and plays a critical role in NF-κB activation and inflammation regulation.
LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1, activating canonical NF-κB and JNK signaling pathways.
This process interferes with TNF-induced cell death, preventing inflammation.
LUBAC is recruited to the TNF-R1 signaling complex following polyubiquitination by BIRC2/BIRC3 and stabilizes the complex.
Together with FAM105B (otulin), LUBAC regulates canonical Wnt signaling during angiogenesis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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