Thermo Fisher Scientific Integrin beta 5 Monoclonal Antibody (KN52), eBioscience
Integrin beta 5 단백질을 인식하는 KN52 단클론 항체로, 인간, 햄스터, 마우스에 반응합니다. Flow cytometry 등 다양한 응용에 사용 가능하며, 세포 이동 억제 효과가 보고되었습니다. 비결합형 액상 항체로 0.5 mg/mL 농도이며, 4°C에서 보관합니다.
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Thermo Fisher Scientific Integrin beta 5 Monoclonal Antibody (KN52), eBioscience
Applications and Tested Dilutions
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | 1 publication |
| Immunocytochemistry (ICC/IF) | - | 1 publication |
| Flow Cytometry (Flow) | 0.25 µg/test | 4 publications |
| Neutralization (Neu) | - | 2 publications |
| Functional Assay (Functional) | - | 3 publications |
| Inhibition Assays (IA) | - | 2 publications |
| Blocking Assay (BLOCK) | - | 1 publication |
| Affinity Purification (AP) | - | 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Hamster, Human, Mouse |
| Published Species | Human, Mouse, Rat |
| Host / Isotype | Mouse / IgG1, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | KN52 |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2864898 |
Additional Formats
Product Specific Information
The KN52 antibody reacts with human integrin beta 5, an approximately 100,000 Mr (reduced) and 95,000 Mr (nonreduced) member of the integrin family. Only the alpha v subunit associates with integrin beta 5 to form the vitronectin receptor complex. This complex binds to the basic domain of Tat (sequence RKKRRQRRR). Integrin beta 5 is found on carcinoma, hepatoma, and fibroblast cell lines, but absent from lymphoblastoid cells and platelets.
The KN52 monoclonal antibody has been shown to inhibit migration.
Applications Reported: Flow cytometric analysis.
Applications Tested: Tested by flow cytometric analysis of CHO, A549, and normal human peripheral blood cells. Recommended ≤0.25 µg/test in 100 µL final volume. Optimal titration advised.
Purity: >90% (SDS-PAGE)
Aggregation: <10% (HPLC)
Filtration: 0.2 µm post-manufacturing filtered
Target Information
Integrins are extracellular matrix (ECM) receptor proteins located on cell surfaces, composed of alpha and beta transmembrane glycoprotein subunits. Approximately 22 different integrins exist, each with specific alpha/beta combinations. They bind ligands with low affinity, requiring clustering for effective ECM binding. Integrins interact with various ligands including laminin, and their cytoplasmic domains mediate actin cytoskeleton interaction and signaling.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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