Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ESR1/3373), Biotin
Human Estrogen Receptor alpha(ESR1) 인식 단일클론 항체로, Biotin으로 표지되어 있습니다. IHC 및 Peptide Array 등 다양한 응용에 사용 가능하며, 고순도 Protein A/G 정제 및 안정적 PBS 버퍼로 제공됩니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- 2099-MSM23-B1
- 판매단위
- pk
카탈로그
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 1–2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2a, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESR1/3373 |
| Immunogen | Recombinant full-length human Estrogen Receptor alpha protein |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 100 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Additional Formats
Target Information
Estrogen Receptors (ER) belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor acts as a ligand-activated transcription factor that, upon binding to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. This binding regulates gene transcription positively or negatively through coactivator or corepressor proteins.
Two receptor forms exist — alpha and beta — encoded by separate genes (ESR1 and ESR2). Alternative RNA splicing produces at least four estrogen receptor-alpha isoforms (Isoform 1: 66 kDa, Isoform 2: 53 kDa, Isoform 3: 47 kDa, Isoform 4: 35 kDa). Estrogen receptors are broadly expressed in various tissues, essential for sexual development and reproductive function, and also play roles in bone and other tissues. They are implicated in diseases including breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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