Thermo Fisher Scientific Estrogen Receptor, alpha (Marker of Estrogen Dependence) Monoclonal Antibody (ESR1/3342)
인간 Estrogen Receptor α(ESR1)을 인식하는 단클론 항체로, IHC 및 Peptide Array 분석에 적합합니다. Mouse IgG2b, kappa 아이소타입이며, 1 mg/mL 농도의 액상 형태로 제공됩니다. 단백질 A/G 정제, PBS(pH 7.4) 버퍼에 보존제 없이 저장됩니다.
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Applications
Immunohistochemistry (Paraffin) (IHC (P))
- Tested Dilution: Assay-dependent
Immunohistochemistry (PFA fixed) (IHC (PFA))
- Tested Dilution: 0.1–0.2 µg/mL
Peptide Array (Array)
- Tested Dilution: Assay-dependent
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG2b, kappa |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ESR1/3342 |
| Immunogen | Recombinant full-length human Estrogen Receptor alpha protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
Target Information
Estrogen Receptors (ER) are members of the steroid/thyroid hormone receptor superfamily of nuclear receptors. The estrogen receptor is a ligand-activated transcription factor that, when bound to estrogen, undergoes a conformational change enabling dimerization and binding to estrogen response elements (ERE) in DNA. ERs regulate gene transcription by recruiting coactivator or corepressor proteins.
There are two forms of the estrogen receptor, alpha (ESR1) and beta (ESR2), encoded by separate genes. Alternative RNA splicing produces multiple ER-alpha isoforms (66, 53, 47, and 35 kDa).
ERs are expressed in various tissues and are vital for sexual development, reproductive function, and bone health. They are implicated in diseases such as breast cancer, endometrial cancer, and osteoporosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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