Thermo Fisher Scientific CD328 (Siglec7) Monoclonal Antibody (S7.7), FITC
인간 Siglec-7 (CD328)을 인식하는 단클론 항체로 NK 세포 및 면역세포 연구에 적합. FITC 형광 표지로 유세포 분석에 사용 가능. Protein G 정제, PBS + 1% BSA 저장. 4°C 단기 보관, -20°C 장기 보관 권장.
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Applications
- Flow Cytometry (Flow): Neat-1:10
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | S7.7 |
| Immunogen | Siglec-7 3T3 transfected cells |
| Conjugate | FITC |
| Excitation / Emission Max | 498 / 517 nm |
| Form | Liquid |
| Concentration | 0.1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS with 1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. Store in the dark. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2745170 |
Additional Formats
- Unconjugated (MA5-28200)
- Custom conjugation available upon request
Product Specific Information
Mouse anti-Human Siglec-7 antibody, clone S7.7 recognizes human Sialic acid-binding Ig-like lectin 7 (CD328), a putative adhesion molecule and member of the Ig superfamily. It is predominantly expressed by both resting and activated natural killer (NK) cells, and also at lower levels by monocytes, granulocytes, monocyte-derived macrophages, dendritic cells, and a small population of CD8+ memory T cells.
Target Information
Siglec-7 is a putative adhesion molecule that mediates sialic acid-dependent binding to cells. It preferentially binds to α2,3- and α2,6-linked sialic acid and disialogangliosides. The sialic acid recognition site may be masked by cis interactions with sialic acids on the same cell surface. In immune response, it may act as an inhibitory receptor upon ligand-induced tyrosine phosphorylation by recruiting cytoplasmic phosphatases that block signal transduction. It mediates inhibition of NK cell cytotoxicity and may play a role in hematopoiesis by inhibiting differentiation of CD34+ precursors toward myelomonocytic lineage and proliferation of leukemic myeloid cells (in vitro).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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