Thermo Fisher Scientific p16INK4a Recombinant Rabbit Monoclonal Antibody (10H23L14)
인간 p16INK4a 단백질을 인식하는 재조합 토끼 단클론 항체입니다. Western blot과 면역세포화학(ICC/IF)에 적합하며, 고순도의 Protein A 정제 항체입니다. 단기 4°C, 장기 -20°C 보관이 권장됩니다. 연구용으로만 사용 가능합니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:100 |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Expression System | Expi293 |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | 10H23L14 |
| Immunogen | Peptides corresponding to human p16INK4a (aa1–aa15, aa137–aa156) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS, pH 7.4 |
| Contains | 0.09% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Wet ice |
| RRID | AB_2848244 |
Product Specific Information
This antibody is predicted to react with Mouse, Rat, and Bovine.
Target Information
The p16INK4a gene produces multiple transcript variants differing in their first exons. At least three alternatively spliced variants encode distinct proteins, two of which are structurally related isoforms functioning as CDK4 kinase inhibitors. Another transcript includes an alternate first exon located 20 Kb upstream, encoding the ARF protein that stabilizes tumor suppressor p53 by interacting with and sequestering MDM2. Despite structural differences, both CDK inhibitor isoforms and the ARF product contribute to G1 phase cell cycle control. This gene is frequently mutated or deleted in various tumors and serves as an important tumor suppressor gene.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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