Thermo Fisher Scientific Estrogen Receptor beta (ER beta) Polyclonal Antibody
Rabbit polyclonal antibody targeting human Estrogen Receptor beta (ERβ). Validated for WB and IHC-P applications. Unconjugated, purified via antigen affinity chromatography. Supplied in PBS buffer with sodium azide. For research use only.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC-P) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to the C-terminus of human Estrogen Receptor Beta |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: MCF-7, Breast carcinoma
- Cellular location: Nuclear
Target Information
Estrogen Receptor beta (ERβ, NR3A2) protein is approximately 55 kDa, with isoforms ranging from 36–59 kDa. Human ERβ was initially cloned from testis. Estrogen receptors belong to the steroid/thyroid hormone receptor superfamily of nuclear receptors. When bound to estrogen, ERβ acts as a ligand-activated transcription factor, inducing dimerization and binding to estrogen response elements (ERE) in DNA, thereby regulating gene transcription through coactivator or corepressor recruitment.
Two forms of estrogen receptor exist—alpha (ESR1) and beta (ESR2). ERβ binds estrogens with similar affinity to ERα and can inhibit ERα activity in reproductive tissues. ERβ is widely expressed in many tissues and may function as a tumor suppressor, with roles in prostate cancer, medullary thyroid carcinoma, cardiovascular disease risk, and other conditions.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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