Thermo Fisher Scientific ITGA4 Monoclonal Antibody (HP2/1)
인간 CD49d (Integrin α4, ITGA4)을 인식하는 마우스 단클론 항체로, 다양한 종에서 반응합니다. WB, IHC(F), ICC/IF, Flow Cytometry, IP, Functional Assay 등에 사용 가능합니다. VLA-4 매개 세포 부착 연구에 적합하며, VCAM-1 결합 억제 기능을 가집니다.
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific ITGA4 Monoclonal Antibody (HP2/1)
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | - | View 1 publication |
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent | - |
| Immunocytochemistry (ICC/IF) | 5 µg/mL | - |
| Flow Cytometry (Flow) | 1 µg/10^5 cells | - |
| Immunoprecipitation (IP) | Assay-dependent | View 1 publication |
| Functional Assay | Assay-dependent | - |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Many, Mouse, Rat |
| Published Species | Not Applicable |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | HP2/1 |
| Immunogen | JM leukemia line (target: CD49d / Integrin alpha 4, UniProt ID: P13612-1, antigen range: 1–1032 aa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Purified |
| Storage Buffer | PBS |
| Contains | 0.1% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_928544 |
Product Specific Information
Clone HP2/1 binds to both intact and the 80 kDa fragment of integrin alpha-4.
This antibody is useful for studies of VLA-4–mediated adhesion and its interaction with VCAM-1, and has been shown to inhibit cell binding to soluble VCAM-1.
This product contains sodium azide; removal by dialysis is recommended prior to use in functional assays.
Mouse anti-Human CD49d monoclonal antibody (clone HP2/1) recognizes human CD49d, also known as integrin alpha-4 or the VLA-4 subunit alpha.
Target Information
Integrin alpha 4 (CD49d, ITGA4) is a member of the integrin alpha chain family.
Integrins are heterodimeric membrane proteins composed of alpha and beta chains. The alpha4 chain associates with either beta1 or beta7 chains.
Ligands for integrin alpha4 include MadCAM, VCAM, and fibronectin. MadCAM is the principal ligand for integrin alpha4β7.
It has been demonstrated that HIV-1 envelope proteins can mimic MadCAM by binding to and signaling through integrin alpha4β7, the gut mucosal homing receptor for peripheral T cells.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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