Thermo Fisher Scientific TRPV6 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

Reconstitution: Add 25 µL, 50 µL, or 0.2 mL of double distilled water (DDW) depending on sample size.
The antibody ships as a lyophilized powder at room temperature. Upon arrival, store at -20°C.
Reconstituted solution can be stored at 4°C for up to 1 week. For longer storage, aliquot and keep at -20°C.
Avoid multiple freeze/thaw cycles. Centrifuge all antibody preparations before use (10,000 × g, 5 min).

Target Information

TRPV6 is a calcium-permeable channel involved in neurotransmission, muscle contraction, and exocytosis by providing intracellular calcium as a second messenger.
Transcellular calcium transport may be regulated by vitamin D, parathyroid hormone (PTH), or calcitonin (CALCA).
This calcium-selective cation channel contributes to Ca(2+) uptake in various tissues, including intestinal reabsorption.
Activated by low internal calcium levels and exhibits inward rectification.
Inactivation occurs via both rapid Ca(2+)-dependent and slower Ca(2+)-calmodulin-dependent mechanisms, which may be regulated by phosphorylation.
In vitro, inhibited by Mg(2+) in a voltage-independent manner.
Forms heteromeric assemblies with TRPV5, modifying channel properties and voltage-dependent gating.
Interacts with TRPV5, S100A10, ANAX2-S100A10 heterotetramer, BSPRY, and calmodulin.
Interaction with S100A10 is required for trafficking to the plasma membrane.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.