Thermo Fisher Scientific Human Activated Protein C (Dansyl-EGR-CK) Native Protein

Applications

• Control (Ctrl): Assay-dependent

Product Specifications

Product Specific Information

RP-43096 contains native human Activated Protein C (Dansyl-EGR-CK) protein.
RP-43096 may be used as a positive control in many immunological assays.
The product is of human blood/plasma origin. Although the starting material was tested prior to initiation of the manufacturing process, and was found negative or nonreactive for anti-HIV-1/2, HIV-1 antigen(s), HBsAg, STS, anti-HCV, anti-HBcore and anti-HTLV I & II, extreme caution should be used when handling this material as there is a margin of error in all tests.
This product is to be used for in vitro research purposes only, and is not intended for clinical or diagnostic use.

Target Information

Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex. Activated Protein C contains a serine protease domain and functions in degradation of activated coagulation factors V and VIII.
Protein C is produced in the liver and composed of two polypeptide chains. The 62 kDa proenzyme is activated by thrombin bound to an endothelial receptor, and the active enzyme (55 kDa) cleaves factors Va and VIIIa, thereby inhibiting blood coagulation.
Normal human plasma concentrations are approximately 1–3 ng/mL for the active enzyme and around 3 µg/mL for the proenzyme due to rapid turnover.
Mutations in the Protein C gene have been linked to thrombophilia, protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.