Thermo Fisher Scientific Aggrecan/AGC1 Polyclonal Antibody
Aggrecan 단백질을 인식하는 토끼 폴리클로날 항체로, 인간, 마우스, 랫트 시료에 반응합니다. Western blot 및 파라핀 조직 면역조직화학(IHC) 분석에 적합하며, 항원 친화 크로마토그래피로 정제되었습니다. 단기 4°C, 장기 -20°C 보관 권장.
- 판매단위
- pk
카탈로그
1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific Aggrecan/AGC1 Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to the 380–400 aa of human ACAN protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Mouse embryonic tissue
- Cellular location: Extracellular, Membrane
Target Information
Aggrecan, also known as cartilage-specific proteoglycan core protein (CSPCP) or chondroitin sulfate proteoglycan 1, is encoded by the ACAN gene. It is a key component of the extracellular matrix in cartilage and provides resistance to compression. The human form (~250 kDa, 2316 amino acids) has multiple isoforms due to alternative splicing.
Aggrecan has a bottlebrush structure with chondroitin sulfate and keratan sulfate chains attached to a protein core. It contains three interglobular domains (IGDs: G1, G2, G3) involved in aggregation, hyaluronan binding, cell adhesion, and chondrocyte apoptosis. Fragments of aggrecan are released into synovial fluid during osteoarthritis progression due to cleavage by aggrecanase and MMP activity. Antibodies BC-3 and BC-4 detect neo-epitopes of Aggrecanase (ARGSVXXX) and MMP (XXXVDIPEN), respectively.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
Thermo Fisher Scientific 상품 둘러보기
전체보기
문의
0개 · 배송·재고 문의는 실시간 상담이 빠릅니다아직 등록된 문의가 없어요.