Thermo Fisher Scientific Troponin I Polyclonal Antibody
Cardiac Troponin I에 특이적인 Rabbit Polyclonal 항체로, WB 및 IHC(P) 실험에 적합. 인간, 생쥐, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 심근 손상 연구 및 심근 단백질 분석에 유용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A synthetic peptide corresponding to inter-segment of human Troponin I Cardiac isoform protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: Cardiac Muscle
- Cellular location: Bands of Myofibrils
Target Information
Cardiac Troponin I (TnI) is an integral inhibitory protein in cardiac muscle, forming a complex with troponin C (TnC) and troponin T (TnT). The TnT subunit binds to tropomyosin to form a troponin-tropomyosin complex, stabilized by TnI binding to actin within muscle thin filaments.
Calcium binding to TnC induces structural changes that release the inhibitory region of TnI from actin, enabling myosin attachment and muscle contraction.
Measurement of blood TnI and TnT levels is a key diagnostic indicator for heart muscle damage and helps differentiate angina from myocardial infarction.
Cardiac Troponin I also inhibits angiogenesis in vivo and in vitro. Mutations in the Cardiac Troponin I gene are associated with familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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