Thermo Fisher Scientific CD209 (DC-SIGN) Monoclonal Antibody (eB-h209), APC, eBioscience
인간 CD209 (DC-SIGN)을 인식하는 eB-h209 단클론 항체로, APC 형광체가 결합된 제품입니다. Flow Cytometry 분석용으로 최적화되어 있으며, 5 µL/test로 사용 가능합니다. 인간 수지상세포 및 말초혈액세포 분석에 적합하며, 고순도 친화 크로마토그래피로 정제되었습니다.
- 카탈로그번호
- 17-2099-42
- 판매단위
- pk
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1개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD209 (DC-SIGN) Monoclonal Antibody (eB-h209), APC, eBioscience
Thermo Fisher Scientific CD209 (DC-SIGN) Monoclonal Antibody (eB-h209), APC, eBioscience™
Applications
- Flow Cytometry (Flow)
Tested Dilution: 5 µL (0.125 µg)/test
Publications: View 4 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Rat / IgG2a, kappa |
| Recommended Isotype Control | Rat IgG2a kappa Isotype Control (eBR2a), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eB-h209 |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 5 µL/test |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2, with 0.2% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11039758 |
Available Formats
Product Specific Information
The eB-h209 monoclonal antibody reacts with human CD209 (DC-SIGN), a 44 kDa type II transmembrane protein containing a C-type lectin binding domain.
DC-SIGN binds ICAM-3, ICAM-2, and HIV virus, and is preferentially expressed on human dendritic cells. It is thought to function as a receptor for HIV capture and transmission to T cells, supporting the primary immune response.
The eB-h209 clone was developed against a C-terminal peptide of human DC-SIGN.
Applications Reported: Flow cytometric analysis
Applications Tested: Pre-titrated and validated for flow cytometry of cultured human dendritic and peripheral blood cells
Recommended Use: 5 µL (0.125 µg) per test (100 µL final volume, 10⁵–10⁸ cells/test)
Excitation: 633–647 nm; Emission: 660 nm; Laser: Red Laser
Filtration: 0.2 µm post-manufacturing filtered
Target Information
The CD209 gene encodes a transmembrane receptor known as DC-SIGN, expressed on dendritic cells and macrophages.
This receptor is part of the innate immune system, recognizing diverse pathogens such as parasites and viruses.
The protein comprises:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region mediates both pathogen recognition and cell adhesion via carbohydrate ligand binding.
Neck domain variations affect ligand binding avidity.
Closely related to L-SIGN (GeneID 10332), differing in ligand-binding properties and tissue distribution.
Alternative splicing results in multiple isoforms.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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