Thermo Fisher Scientific CD209b (SIGN-R1) Monoclonal Antibody (eBio22D1 (22D1)), APC, eBioscience
마우스 SIGNR1(CD209b)을 인식하는 APC 결합 단클론 항체로, 유세포분석에 적합합니다. 고순도의 Armenian hamster IgG로 제작되었으며, 0.2 µm 여과 후 PBS 완충액에 보존됩니다. 4°C 암소 보관, 동결 금지. 연구용으로만 사용 가능합니다.
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Applications
Immunohistochemistry (Frozen) (IHC (F))
- Tested Dilution: -
- View 1 publication
Flow Cytometry (Flow)
- Tested Dilution: 1 µg/test
- View 5 publications
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), APC, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | eBio22D1 (22D1) |
| Conjugate | APC |
| Excitation / Emission Max | 651 / 660 nm |
| Form | Liquid |
| Concentration | 0.2 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11149350 |
Additional Formats
Product Specific Information
The eBio22D1 monoclonal antibody reacts with mouse SIGNR1 (CD209b), a type II transmembrane C-type lectin identified as a mouse homologue of human DC-SIGN. SIGNR1 is highly expressed in splenic marginal zone macrophages and lymph node medullary macrophages, where it mediates uptake of dextran polysaccharides, including capsular polysaccharides of Streptococcus pneumoniae. SIGNR1 associates with TLR4/MD2, suggesting a role in LPS recognition. SIGNR1-deficient mice show defective catabolism of complement component C3, and SIGNR1 binds complement C1q to form a non-conventional C3 convertase. The eBio22D1 antibody shows no cross-reactivity with SIGNR1, SIGNR2, SIGNR3, or SIGNR4.
Applications Reported: Flow cytometric analysis
Applications Tested: Tested on young mouse splenocytes at ≤1 µg/test (100 µL final volume; 10⁵–10⁸ cells/test). Optimize titration for best performance.
- Excitation: 633–647 nm
- Emission: 660 nm
- Laser: Red Laser
- Filtration: 0.2 µm post-manufacturing filtered
Target Information
SIGNR1 is a type II transmembrane C-type lectin expressed in splenic marginal zone and lymph node medullary macrophages. It mediates uptake of dextran polysaccharides and interacts with TLR4/MD2, contributing to LPS recognition. SIGNR1 also binds complement C1q, forming a non-conventional C3 convertase, and its deficiency leads to impaired C3 catabolism.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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