Thermo Fisher Scientific PKR Monoclonal Antibody (6H3A10)
PKR 단백질을 인식하는 마우스 단클론 항체로, 인간 시료에 반응합니다. WB, IHC, Flow, ELISA 등 다양한 응용에 사용 가능하며, 고순도 Protein G 정제 및 PBS 버퍼로 제공됩니다. 바이러스 방어 및 세포 신호 연구에 적합합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Flow Cytometry (Flow) | 1:200–1:400 |
| ELISA | 1:10,000 |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 6H3A10 |
| Immunogen | Purified recombinant fragment of human EIF2AK2 (aa: 329–551) expressed in E. coli |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein G |
| Storage Buffer | PBS |
| Contains | 0.05% sodium azide |
| Storage Conditions | Store at 4°C short term. For long term, store at –20°C avoiding freeze/thaw cycles. |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_2898428 |
Product Specific Information
This antibody has been tested in indirect ELISA.
Target Information
EIF2AK2 (PKR) is one of four kinases that specifically phosphorylate Ser51 of translation initiation factor eIF2-alpha in response to various environmental stresses. PKR plays a key role in antiviral defense through activation by double-stranded RNA produced during viral infection. It is involved in IFN-induced innate antiviral responses, virus-induced apoptosis, and regulation of cell growth and differentiation.
PKR induces apoptosis by up-regulating Fas expression and mediates FADD/Caspase-8 death signaling. Upon viral infection, PKR acts as a dual-function protein, activating both cell survival and death pathways via kinase-independent and dependent mechanisms. It regulates multiple signaling pathways including NF-κB, p53, p38, and PDGF. PKR has been implicated in tumor suppression, malignancy, and several neurodegenerative diseases such as Alzheimer’s, Huntington’s, and amyotrophic lateral sclerosis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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