Thermo Fisher Scientific Dynactin 2 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1 µg/mL

Immunocytochemistry (ICC/IF)

• Tested Dilution: 5–15 µg/mL

Product Specifications

Product Specific Information

This antibody detects human Dynactin Subunit 2/DCTN2 in direct ELISAs and human and mouse Dynactin Subunit 2/DCTN2 in Western blots.
In direct ELISAs, less than 1% cross-reactivity with recombinant human DCTN1 is observed.
Reconstitute in sterile PBS to a final concentration of 0.2 mg/mL.

Target Information

This gene encodes a 50-kD subunit of dynactin, a macromolecular complex consisting of 10–11 subunits ranging from 22 to 150 kDa. Dynactin binds to both microtubules and cytoplasmic dynein and is involved in diverse cellular functions such as:

• ER-to-Golgi transport
• Centripetal movement of lysosomes and endosomes
• Spindle formation and chromosome movement
• Nuclear positioning and axonogenesis

This subunit is present in 4–5 copies per dynactin molecule and contains three short alpha-helical coiled-coil domains that may mediate association with self or other dynactin subunits. It may interact directly with the largest subunit (p150) of dynactin and affix p150 in place.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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