Thermo Fisher Scientific COX15 Polyclonal Antibody
COX15 단백질을 인식하는 Thermo Fisher Scientific의 토끼 폴리클로날 항체입니다. Western blot, IHC, ICC/IF, ELISA에 적합하며 인간, 마우스, 랫트 시료에 반응합니다. 미토콘드리아 막 단백질 분석 및 산화적 인산화 연구에 유용합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:50–1:100 |
| Immunocytochemistry (ICC/IF) | 1:50–1:100 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Synthetic peptide corresponding to amino acids 150–250 of human COX15 (NP_510870.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.43 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805871 |
Product Specific Information
Immunogen sequence:
YSHRMWGRLV GLVYILPAAY FWRKGWLSRG MKGRVLALCG LVCFQGLLGW YMVKSGLEEK SDSHDIPRVS QYRLAAHLGS ALVLYCASLW TSLSLLLPPH K
Positive Samples:
U-251MG, A-431, Jurkat, Mouse heart, Mouse kidney, Mouse lung, Rat testis
Cellular Location:
Mitochondrion membrane, Multi-pass membrane protein
Target Information
The cytochrome c oxidase (COX) family of proteins functions as the final electron donor in the respiratory chain to drive a proton gradient across the inner mitochondrial membrane, resulting in the production of water.
The mammalian COX apoenzyme is a dimer with 13 subunits per monomer, encoded by both mitochondrial and nuclear genes.
COX15 (cytochrome c oxidase assembly protein COX15 homolog) is a 410 amino acid multi-pass mitochondrial membrane protein of the COX15/ctaA family. It exists as two alternatively spliced isoforms and is highly expressed in tissues with elevated oxidative phosphorylation activity such as brain, heart, and muscle.
Defects in COX15 are associated with Leigh syndrome and cytochrome c oxidase deficiency (COX deficiency).
Safety Information
⚠ WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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