Thermo Fisher Scientific DC-SIGN Polyclonal Antibody
Rabbit polyclonal antibody recognizing DC-SIGN (CD209) in human, mouse, and rat. Validated for WB, ICC/IF, and ELISA. Supplied as liquid, unconjugated form with 0.33 mg/mL concentration. Suitable for research use in innate immune receptor studies.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:1,000 |
| Immunocytochemistry (ICC/IF) | 1:50–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Property | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 265–404 of human CD209 (NP_066978.1) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.33 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805870 |
Product Specific Information
Immunogen sequence:
GNCYFMSNSQ RNWHDSITAC KEVGAQLVVI KSAEEQNFLQ LQSSRSNRFT WMGLSDLNQE GTWQWVDGSP LLPSFKQYWN RGEPNNVGEE DCAEFSGNGW NDDKCNLAKF WICKKSAASC SRDEEQFLSP APATPNPPPA
Positive Samples: NIH/3T3, Mouse liver, Mouse kidney, Rat liver, Rat kidney
Cellular Location: Cell membrane, Single-pass type II membrane protein
Target Information
This gene encodes a transmembrane receptor known as DC-SIGN (CD209), expressed on dendritic cells and macrophages. It plays a key role in the innate immune system by recognizing a wide range of pathogens, including parasites and viruses. The protein consists of three main domains:
- N-terminal transmembrane domain
- Tandem-repeat neck domain
- C-type lectin carbohydrate recognition domain
The extracellular region functions as both a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on microbial and endogenous cell surfaces. The neck domain facilitates homo-oligomerization, enhancing multivalent ligand binding. Variations in the neck domain repeat number can affect binding affinity. DC-SIGN is closely related to L-SIGN (GeneID 10332), differing in ligand-binding properties and tissue distribution. Alternative splicing produces multiple variants.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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