Thermo Fisher Scientific Importin 11 Polyclonal Antibody
Importin 11 단백질을 표적하는 Thermo Fisher Scientific의 Rabbit Polyclonal Antibody로, Human 및 Mouse 시료에 반응합니다. Western blot과 ELISA에 적합하며, 액상 형태로 1.37 mg/mL 농도입니다. 핵 단백질 수송 연구용으로 사용됩니다.
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Applications
Western Blot (WB)
- Tested Dilution: 1:500–1:2,000
ELISA
- Tested Dilution: 1 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 776–975 of human IPO11 (NP_0574223) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.37 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.01% thimerosal |
| Storage Conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2805875 |
Product Specific Information
Immunogen sequence:
KGIIEGERYP VVMSTYLGVM GRVLLQNTSF FSSLLNEMAH KFNQEMDQLL GNMIEMWVDR MDNITQPERR KLSALALLSL LPSDNSVIQD KFCGIINISV EGLHDVMTED PETGTYKDCM LMSHLEEPKV TEDEEPPTEQ DKRKKMLALK DPVHTVSLQQ FIYEKLKAQQ EMLGEQGFQS LMETVDTEIV TQLQEFLQGF
Positive Samples:
HeLa, 293T, A-549, Mouse heart, Mouse kidney, Mouse lung, Mouse spleen, Mouse testis
Cellular Location:
Cytoplasm, Nucleus
Target Information
IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin. The complex is translocated through the pore by a Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, causing dissociation of the complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. Directionality of nuclear import is conferred by asymmetric GTP/GDP-bound Ran distribution. IPO11 mediates nuclear import of UBE2E3 and RPL12.
⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
제품 이미지
(이미지 파일명: PA5-89980_Importin_11_Q9UI26-1_Rabbit.svg, PA5-89980_Importin_11_Q9UI26-1_Rabbit_PDP.jpeg)
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