Thermo Fisher Scientific Importin 11 Polyclonal Antibody

Applications

Western Blot (WB)

• Tested Dilution: 1:500–1:2,000

ELISA

• Tested Dilution: 1 µg/mL

Product Specifications

Product Specific Information

Immunogen sequence:
KGIIEGERYP VVMSTYLGVM GRVLLQNTSF FSSLLNEMAH KFNQEMDQLL GNMIEMWVDR MDNITQPERR KLSALALLSL LPSDNSVIQD KFCGIINISV EGLHDVMTED PETGTYKDCM LMSHLEEPKV TEDEEPPTEQ DKRKKMLALK DPVHTVSLQQ FIYEKLKAQQ EMLGEQGFQS LMETVDTEIV TQLQEFLQGF

Positive Samples:
HeLa, 293T, A-549, Mouse heart, Mouse kidney, Mouse lung, Mouse spleen, Mouse testis

Cellular Location:
Cytoplasm, Nucleus

Target Information

IPO11 functions in nuclear protein import as a nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and mediates docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin. The complex is translocated through the pore by a Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin, causing dissociation of the complex, and importin is re-exported to the cytoplasm where GTP hydrolysis releases Ran. Directionality of nuclear import is conferred by asymmetric GTP/GDP-bound Ran distribution. IPO11 mediates nuclear import of UBE2E3 and RPL12.

⚠ WARNING:
This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm.
For more information, visit www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

제품 이미지

(이미지 파일명: PA5-89980_Importin_11_Q9UI26-1_Rabbit.svg, PA5-89980_Importin_11_Q9UI26-1_Rabbit_PDP.jpeg)