Thermo Fisher Scientific Importin 11 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 776-975 of human IPO11 (NP_0574223) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:Importin 11,uniProtId:Q9UI26-1,ncbiNodeId:9606,antigenRange:776-975,antigenLength:975,antigenImageFileName:PA5-89980_Importin_11_Q9UI26-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89980_Importin_11_Q9UI26-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.37 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805875

Product Specific Information

Immunogen sequence: KGIIEGERYP VVMSTYLGVM GRVLLQNTSF FSSLLNEMAH KFNQEMDQLL GNMIEMWVDR MDNITQPERR KLSALALLSL LPSDNSVIQD KFCGIINISV EGLHDVMTED PETGTYKDCM LMSHLEEPKV TEDEEPPTEQ DKRKKMLALK DPVHTVSLQQ FIYEKLKAQQ EMLGEQGFQS LMETVDTEIV TQLQEFLQGF; Positive Samples: HeLa, 293T, A-549, Mouse heart, Mouse kidney, Mouse lung, Mouse spleen, Mouse testis; Cellular Location: Cytoplasm, Nucleus

Target Information

IPO11 functions in nuclear protein import as nuclear transport receptor. It serves as receptor for nuclear localization signals (NLS) in cargo substrates and is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP-and GDP-bound forms of Ran between the cytoplasm and nucleus. It mediates the nuclear import of UBE2E3, and of RPL12.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.