Thermo Fisher Scientific LZTR2 Polyclonal Antibody

Applications

Tested Dilution

Publications

Western Blot (WB)

1:500-1:2,000

-

ELISA (ELISA)

1 µg/mL

-

Product Specifications

Species Reactivity

Human, Mouse

Host/Isotype

Rabbit / IgG

Class

Polyclonal

Type

Antibody

Immunogen

Recombinant fusion protein containing a sequence corresponding to amino acids 250-550 of human SEC16B (NP_1491182) if (typeof window.$mangular === undefined || !window.$mangular) { window.$mangular = {}; } $mangular.antigenJson = \[{targetFamily:LZTR2,uniProtId:Q96JE7-1,ncbiNodeId:9606,antigenRange:250-550,antigenLength:1060,antigenImageFileName:PA5-89978_LZTR2_Q96JE7-1_Rabbit.svg,antigenImageFileNamePDP:PA5-89978_LZTR2_Q96JE7-1_Rabbit_PDP.jpeg,sortOrder:1}\]; $mangular.isB2BCMGT = false; $mangular.isEpitopesModalImageMultiSizeEnabled = true;

View immunogen .st0{fill:#FFFFFF;} .st1{fill:#1E8AE7;}

Conjugate

Unconjugated Unconjugated Unconjugated

Form

Liquid

Concentration

1.75 mg/mL

Purification

Affinity Chromatography

Storage buffer

PBS, pH 7.3, with 50% glycerol

Contains

0.01% thimerosal

Storage conditions

-20° C, Avoid Freeze/Thaw Cycles

Shipping conditions

Wet ice

RRID

AB_2805873

Product Specific Information

Immunogen sequence: DPPASAAWSP VQADVSSAGP KAPMKFYIPH VPVSFGPGGQ LVHVGPSSPT DGQAALVELH SMEVILNDSE EQEEMRSFSG PLIREDVHKV DIMTFCQQKA AQSCKSETLG SRDSALLWQL LVLLCRQNGS MVGSDIAELL MQDCKKLEKY KRQPPVANLI NLTDEDWPVL SSGTPNLLTG EIPPSVETPA QIVEKFTRLL YYGRKKEALE WAMKNHLWGH ALFLSSKMDP QTYSWVMSGF TSTLALNDPL QTLFQLMSGR IPQAATCCGE KQWGDWRPHL AVILSNQAGD PELYQRAIVA I; Positive Samples: HeLa, Mouse pancreas; Cellular Location: Endoplasmic reticulum membrane, Golgi apparatus membrane, Peripheral membrane protein

Target Information

LZTR2, also known as RGPR-p117, is a member of the BTB-kelch superfamily and was initially described as a nuclear factor I (NFI) binding protein and transcriptional regulator of the regucalcin gene. LZTR2 is cytoplasmically localized but is thought to translocate to the nucleus, a process mediated by protein kinase C signaling following hormonal stimulation. Recent evidence has suggested that there is a strong correlation of single nucleotide polymorphisms of LZTR2 with obesity in the Japanese population similar to that seen with the TMEM18 gene and the GNPDA2, BDNF, FAIM2, and MC4R genes with obesity in Caucasian populations, suggesting LZTR2 may play a role in metabolism and obesity risk.

⚠WARNING: This product can expose you to chemicals including mercury, which is known to the State of California to cause birth defects or other reproductive harm. For more information go to www.P65Warnings.ca.gov.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.