Thermo Fisher Scientific CD61/Integrin beta-3/Platelet Glycoprotein IIIa Recombinant Mouse Monoclonal Antibody (rITGB3, 1713)
인간 CD61(Integrin beta-3)을 인식하는 마우스 재조합 단클론 항체로, IHC(P) 등 면역조직화학 분석에 적합합니다. HEK293 세포에서 발현되었으며, Protein A/G로 정제되었습니다. 4°C 보관, 연구용 전용 제품입니다.
- 카탈로그번호
- 3690-MSM4-P0
- 판매단위
- pk
카탈로그
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Applications
- Immunohistochemistry (Paraffin) (IHC (P)): 1–2 µg/mL
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rITGB3, 1713 |
| Immunogen | Recombinant full-length human CD61 (Integrin beta 3) protein (UniProt ID: P05106-1, amino acids 1–788) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 200 µg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4, with 0.05% BSA |
| Contains | 0.05% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- For immunohistochemistry (PFA fixed): incubate antibody for 30 minutes at room temperature.
- Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA (pH 9.0) for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It functions in platelet aggregation and serves as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin.
CD61 is a 105 kDa glycoprotein that associates with alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets, megakaryocytes, endothelial cells, monocytes, and osteoclasts.
The CD61 protein consists of alpha and beta chains that can combine with multiple partners to form different integrins. CD61 plays roles in cell adhesion and cell-surface mediated signaling.
Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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