Thermo Fisher Scientific CD61/Integrin beta-3/Platelet Glycoprotein IIIa Recombinant Mouse Monoclonal Antibody (rITGB3, 1713)
CD61(Integrin beta-3) 인식용 리컴비넌트 마우스 단클론 항체로, IHC(P) 등 다양한 응용에 적합합니다. HEK293 세포에서 발현되었으며, Protein A/G로 정제된 액상 형식입니다. 인간 시료 반응성이 있으며, 보존제 미첨가 PBS 용액에 제공됩니다.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Paraffin) (IHC (P)) | 1–2 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Expression System | HEK293 cells |
| Class | Recombinant Monoclonal |
| Type | Antibody |
| Clone | rITGB3, 1713 |
| Immunogen | Recombinant full-length human CD61 (Integrin beta 3) protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Protein A/G |
| Storage Buffer | PBS, pH 7.4 |
| Contains | No preservative |
| Storage Conditions | -20°C or -80°C if preferred |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.
Target Information
CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin, playing a key role in platelet aggregation.
CD61 (105 kDa) associates with either alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets and megakaryocytes (with CD41), and on endothelial cells, monocytes, and osteoclasts (with CD51).
Like other integrins, CD61 participates in cell adhesion and cell-surface mediated signaling.
Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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