Thermo Fisher Scientific CD61/Integrin beta-3/Platelet Glycoprotein IIIa Recombinant Mouse Monoclonal Antibody (rITGB3, 1713)

Applications and Tested Dilution

Product Specifications

Product Specific Information

Immunohistochemistry (PFA fixed): Incubate antibody for 30 minutes at room temperature.
Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 minutes at 95°C, followed by cooling at room temperature for 20 minutes.

Target Information

CD61 (GPIIIa, ITGB3) is a glycoprotein found on megakaryocytes, platelets, and their precursors. It functions as a receptor for fibrinogen, fibronectin, von Willebrand factor, and vitronectin, playing a key role in platelet aggregation.
CD61 (105 kDa) associates with either alpha IIb integrin (CD41) or alpha V integrin (CD51) at the cell surface. It is expressed on platelets and megakaryocytes (with CD41), and on endothelial cells, monocytes, and osteoclasts (with CD51).
Like other integrins, CD61 participates in cell adhesion and cell-surface mediated signaling.
Diseases associated with CD61 dysfunction include Glanzmann Thrombasthenia and Platelet type-16 Bleeding Disorder.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.