Thermo Fisher Scientific LGR5 Monoclonal Antibody (OTI11B5), TrueMAB
인간 LGR5 단백질(aa 250-550)을 인식하는 마우스 단클론 항체로, Western blot, ICC/IF, Flow cytometry에 적합. 무보존제, 동결건조 형태로 제공되며 재구성 후 1 mg/mL 농도로 사용 가능. 연구용으로만 사용.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500 |
| Immunocytochemistry (ICC/IF) | 1:100 |
| Flow Cytometry (Flow) | 1:100 |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | OTI11B5 |
| Immunogen | Human recombinant protein fragment corresponding to amino acids 250–550 of human LGR5 produced in 293T cells |
| Conjugate | Unconjugated |
| Form | Lyophilized |
| Concentration | 1 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.3, with 8% trehalose |
| Contains | No preservative |
| Storage Conditions | -20°C, avoid freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
For reconstitution, add 100 µL of distilled water to obtain a final antibody concentration of approximately 1 mg/mL.
For conjugation experiments, perform an additional desalting step (recommended: Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).
Target Information
G protein-coupled receptor GPR49 (LGR5) is expressed in brain, skeletal muscle, placenta, and spinal cord. ESTs have been isolated from normal human brain (amygdala), embryo, and placenta libraries.
GPCRs represent one of the largest families of signaling molecules, characterized by seven membrane-spanning helices and existing in active and inactive forms. They mediate signaling through G-proteins and downstream effectors.
Regulatory mechanisms of GPCRs, including negative regulation, have significant physiological and pharmacological implications. GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough) demonstrate the therapeutic potential of this receptor family.
For Research Use Only. Not for use in diagnostic procedures or resale without authorization.
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