Thermo Fisher Scientific CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), PE, eBioscience

Thermo Fisher Scientific CD357 (AITR/GITR) Monoclonal Antibody (DTA-1), PE, eBioscience™

Applications

• Flow Cytometry (Flow)

Tested Dilution: 0.004 µg/test
Publications: View 16 publications

Product Specifications

Additional Formats Available

• APC
• APC-eFluor 780
• Biotin
• eFluor 450
• FITC
• Functional Grade
• PE-Cyanine7
• PerCP-eFluor 710
• Super Bright 436
• Super Bright 600
• Super Bright 702
• Request custom conjugation

Product Specific Information

The DTA-1 monoclonal antibody reacts with mouse GITR (Glucocorticoid-Induced TNFR family gene, TNFRSF18).
In naive mice, GITR is expressed predominantly by CD4+CD25+ regulatory T cells (Treg) and CD25+ CD4+ CD8- thymocytes.
Stimulation of GITR with DTA-1 antibody abrogates Treg cell-mediated suppression and can induce tumorogenesis.
Administration or removal of GITR-expressing Treg cells may result in organ-specific autoimmune disease.

• Applications Reported: Flow cytometric analysis
• Applications Tested: Tested on mouse splenocytes (≤0.004 µg/test; 100 µL final volume)
• Excitation: 488–561 nm
• Emission: 578 nm
• Laser Compatibility: Blue, Green, Yellow-Green lasers
• Filtration: 0.2 µm post-manufacturing filtered

Target Information

Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also known as GITR or AITR, is encoded by the TNFRSF18 gene located at 1p36.33.
This receptor is upregulated upon T-cell activation and plays a key role in maintaining immunological self-tolerance via CD25(+)CD4(+) regulatory T cells.
Knockout studies indicate roles in CD3-driven T-cell activation and apoptosis regulation.
Three alternatively spliced transcript variants encoding distinct isoforms have been reported.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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