Thermo Fisher Scientific c-erbB-4/HER-4 Monoclonal Antibody (ABM338)
HER4 단백질의 C-말단 합성 펩타이드를 면역원으로 제작된 마우스 단클론 항체. Western blot 및 IHC(P)에서 검증됨. 인간 및 마우스 시료 반응성. 단백질 A로 정제된 액상 항체로, 0.5 mg/mL 농도. 단기 4°C, 장기 -20°C 보관 권장.
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Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 0.1–1 µg/mL |
| Immunohistochemistry (Paraffin) (IHC (P)) | 2–10 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Mouse / IgG1 |
| Class | Monoclonal |
| Type | Antibody |
| Clone | ABM338 |
| Immunogen | A synthetic peptide corresponding to the C-terminus of Her4 protein |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Protein A |
| Storage Buffer | PBS with proprietary stabilizer |
| Contains | 0.01% sodium azide |
| Storage Conditions | Store at 4°C short term; for long term, store at -20°C, avoiding freeze/thaw cycles |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
Product Specific Information
- Positive control: SK-BR-3 cell lysate
- Cellular location: Membrane
Target Information
Oncogene ERBB4 (HER4) is a member of the type I receptor protein tyrosine kinase family, which includes EGFR, ERBB2, and ERBB3.
ERBB4 is activated by neuregulins and other ligands, inducing cellular responses such as mitogenesis and differentiation.
ErbB4 functions as a receptor for heregulin and mediates HGL-stimulated tyrosine phosphorylation. It plays critical roles in signal transduction regulating metabolism, transcription, cell cycle progression, cytoskeletal rearrangement, apoptosis, and differentiation.
Expression of ErbB4 is high in several breast carcinoma cell lines (e.g., T47-D, MDA-MB-453, BT-474, H3396) and in normal tissues such as skeletal muscle, heart, pituitary, brain, and cerebellum.
Low or absent expression is observed in some breast tumor cell lines (e.g., MDA-MB-231, MDA-MB-157, MDA-MB-468, SKBR-3). Elevated ErbB4 levels in certain human tumor cell lines suggest a potential role in malignancy.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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