Thermo Fisher Scientific SLC22A17 Polyclonal Antibody

Applications

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:20–1:50

Product Specifications

Product Specific Information

• Immunogen sequence:
  RWLIVKRQIE EAQSVLRILA ERNRPHGQML GEEAQEALQD LENTCPLPAT SSFSFASLLN
• Highest antigen sequence identity to the following orthologs:
  Mouse - 97%, Rat - 95%

Target Information

The Slc22 family of organic anion and cation transporters (OATs, OCTs, OCTNs) are transmembrane proteins predominantly expressed in kidney and liver.
They contain 12 predicted alpha-helical transmembrane domains (TMDs) and one large extracellular loop between TMDs 1 and 2.
Transporters of the SLC22 family function as:

• Uniporters mediating facilitated diffusion (OCTs)
• Anion exchangers (OAT1, OAT3, URAT1)
• Na(+)/l-carnitine cotransporter (OCTN2)

These transporters are involved in absorption and excretion of drugs, xenobiotics, and endogenous compounds in intestine, liver, and kidney, and perform homeostatic functions in brain and heart.
Mutations in the Slc22 family may cause diseases such as primary systemic carnitine deficiency or idiopathic renal hypouricemia and can affect drug absorption or excretion.
Recent studies show that Slc22A17, acting as a receptor for Lipocalin 2, is highly expressed in hematopoietic stem cells.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.

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