Thermo Fisher Scientific Occludin Polyclonal Antibody
Occludin 단백질을 인식하는 Rabbit Polyclonal Antibody로, WB 및 IHC에 적합합니다. 인간, 마우스, 랫트 시료에 반응하며, 항원 친화 크로마토그래피로 정제되었습니다. 4°C에서 보관하며 연구용으로 사용됩니다.
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Applications
| Application | Tested Dilution | Publications |
|---|---|---|
| Western Blot (WB) | 1 µg/mL | View 3 publications |
| Immunohistochemistry (IHC) | 2.5 µg/mL | View 1 publication |
| In vitro Assay (IV) | - | View 1 publication |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Published Species | Human, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 15 amino acid peptide from near the carboxy terminus of human OCLN |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11154303 |
Product Specific Information
- Suggested positive control: human liver tissue lysate
- PA5-20755 can be used with blocking peptide PEP-0869
- Antibodies should not be exposed to prolonged high temperatures
Target Information
Occludin is a 65 kDa protein that can exist in various phosphorylated forms (up to ~82 kDa). It plays a role in regulating tight junction localization and function. Polyunsaturated fatty acids up-regulate occludin expression, enhancing transendothelial resistance and reducing permeability. Expression levels vary by tissue, with high and continuous expression in brain tissue and lower, discontinuous levels in non-neural tissues. Structural features of occludin are conserved across species. Under-expression of occludin and other tight junction proteins contributes to increased permeability in tumor endothelium, leading to brain tumor edema.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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(이미지 파일명: PA5-20755_Occludin_Q16625-1_Rabbit.svg, PA5-20755_Occludin_Q16625-1_Rabbit_PDP.jpeg)
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