Thermo Fisher Scientific MC4R Polyclonal Antibody
MC4R 단백질을 인식하는 Thermo Fisher Scientific의 폴리클로날 항체로, WB, IHC, ICC/IF에 사용 가능. 인간, 마우스, 랫트 반응성. 항원 친화 크로마토그래피로 정제된 액상 형태. 뇌 조직에서 MC4R 발현 연구에 적합.
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Thermo Fisher Scientific MC4R Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1 µg/mL |
| Immunohistochemistry (IHC) | 2.5 µg/mL |
| Immunocytochemistry (ICC/IF) | 20 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | A 19 amino acid peptide near the amino terminus of human MC4R |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | PBS |
| Contains | 0.02% sodium azide |
| Storage Conditions | Maintain refrigerated at 2–8°C for up to 3 months. For long-term storage, store at -20°C |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_11152201 |
Product Specific Information
- Suggested positive control: rat brain tissue lysate
- PA5-20759 can be used with blocking peptide PEP-0873
Target Information
Expression of MC4R has been reported in brain tissue. Unlike other melanocortin receptors, MC4R is not expressed in adrenal cortex or melanocytes.
G-protein Coupled Receptors (GPCRs) constitute one of the largest families of signaling molecules, sharing a structural motif of seven membrane-spanning helices. These receptors exist in active and inactive forms and are regulated by various ligands through G-protein signaling pathways.
Studies on GPCR regulation have significant implications for cellular physiology and pharmacological research, contributing to the development of major GPCR-targeted drugs such as Zyprexa (Eli Lilly) and Claritin (Schering-Plough).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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