Thermo Fisher Scientific CD80 (B7-1) Monoclonal Antibody (16-10A1), Biotin, eBioscience
마우스 CD80(B7-1) 인식을 위한 16-10A1 클론 단클론 항체로, Biotin 결합형입니다. Flow cytometry에 최적화되어 있으며, 0.125 µg/test 농도로 사용됩니다. 면역세포 활성화 연구 및 T-B 세포 상호작용 분석에 적합합니다.
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3개 옵션 · 카탈로그 번호를 클릭하면 복사됩니다Thermo Fisher Scientific · Thermo Fisher Scientific CD80 (B7-1) Monoclonal Antibody (16-10A1), Biotin, eBioscience
Thermo Fisher Scientific CD80 (B7-1) Monoclonal Antibody (16-10A1), Biotin, eBioscience™
Applications and Tested Dilution
| Application | Tested Dilution | Publications |
|---|---|---|
| Immunohistochemistry (IHC) | - | View 2 publications |
| Immunocytochemistry (ICC/IF) | - | View 1 publication |
| Flow Cytometry (Flow) | 0.125 µg/test | View 74 publications |
Product Specifications
| Specification | Detail |
|---|---|
| Published Species | Mouse |
| Host / Isotype | Armenian hamster / IgG |
| Recommended Isotype Control | Armenian Hamster IgG Isotype Control (eBio299Arm), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 16-10A1 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE! |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_466508 |
| Filtration | 0.2 µm post-manufacturing filtered |
Available Formats
- Unconjugated
- Alexa Fluor 700
- APC
- Brilliant UV 615
- Brilliant UV 737
- Brilliant Violet 480
- Brilliant Violet 605
- Brilliant Violet 711
- Brilliant Violet 786
- eFluor 450
- FITC
- Functional Grade
- PE
- PE-Cyanine5
- PE-Cyanine7
- PerCP-eFluor 710
- Super Bright 436
- Super Bright 600
- Super Bright 645
- Request custom conjugation
Product Specific Information
The 16-10A1 monoclonal antibody reacts with mouse CD80 (B7-1), a 55 kDa member of the Ig superfamily. CD80 is expressed by macrophages, dendritic cells, and activated B cells, as well as activated T cells. It binds with high affinity to CD28 and CD152 (CTLA-4) on T cells, playing a crucial role in T-B cell communication and activation.
- Applications Reported: Suitable for flow cytometric analysis.
- Applications Tested: Validated in flow cytometric analysis of activated mouse splenocytes at ≤0.125 µg/test.
A test is defined as the antibody amount required to stain cells in a final volume of 100 µL. Recommended titration for optimal performance.
Target Information
CD80 (B7-1) and CD86 (B7-2) serve as ligands for T cell costimulatory molecule CD28 and inhibitory receptor CTLA-4 (CD152). Both are expressed on antigen-presenting cells and are essential for T cell activation.
CD80 is rapidly induced on activated B cells and is associated with various cell lines including EBV-transformed and Burkitt’s lymphoma cells. It provides regulatory signals to T lymphocytes via CD28 and CTLA4 binding.
Diseases associated with CD80 dysfunction include gallbladder squamous cell carcinoma and myocarditis.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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