Thermo Fisher Scientific CD84 Monoclonal Antibody (2G7), Biotin, eBioscience
CD84 항원을 인식하는 2G7 클론의 Biotin 결합 단일클론 항체로, 인간 시료에 반응합니다. Flow cytometry 및 동결 절편 면역조직화학에 적합하며, 0.25 µg/test 권장됩니다. 0.5 mg/mL 농도, PBS(pH 7.2) 보관, 4°C 암소 저장.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Immunohistochemistry (Frozen) (IHC (F)) | Assay-dependent |
| Flow Cytometry (Flow) | 0.25 µg/test |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Published Species | Human |
| Host / Isotype | Mouse / IgG1, kappa |
| Recommended Isotype Control | Mouse IgG1 kappa Isotype Control (P3.6.2.8.1), Biotin, eBioscience™ |
| Class | Monoclonal |
| Type | Antibody |
| Clone | 2G7 |
| Conjugate | Biotin |
| Form | Liquid |
| Concentration | 0.5 mg/mL |
| Purification | Affinity chromatography |
| Storage Buffer | PBS, pH 7.2 |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C, store in dark, DO NOT FREEZE |
| Shipping Conditions | Ambient (domestic); Wet ice (international) |
| RRID | AB_914342 |
Available Formats
Product Specific Information
The monoclonal antibody 2G7 reacts with CD84, a transmembrane protein of the Ig SLAM superfamily. CD84 is expressed on mature B cells, a subset of T cells (mainly CD4+CD45RA+), monocytes, and platelets. It is also found on a portion of human hematopoietic progenitor (CD34+) cells. Signaling through CD84 via homotypic interactions involves phosphorylation and recruitment of SAP and EAT-2, leading to IFNγ production and T cell activation.
Applications Reported:
- Flow cytometric analysis
- Immunohistology staining of frozen tissue sections
Applications Tested:
This antibody has been tested by flow cytometric analysis of normal human peripheral blood cells. It can be used at ≤0.25 µg per test (in 100 µL final volume). Cell number per test may vary from 10⁵ to 10⁸ and should be optimized empirically. Antibody titration is recommended for optimal performance.
Filtration: 0.2 µm post-manufacturing filtered.
Target Information
CD84 is expressed on mature B cells and pre-B cell lines, but not on plasma cell lines. It is strongly expressed on tissue macrophages and highly expressed on platelets, with low expression on peripheral blood T cells. CD84 is a highly glycosylated member of the immunoglobulin superfamily and may play a role in leukocyte activation.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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