Thermo Fisher Scientific PMCA4 ATPase Polyclonal Antibody
PMCA4 ATPase 단백질을 인식하는 Thermo Fisher Scientific의 rabbit polyclonal 항체입니다. Western blot과 ELISA에 적합하며, mouse 시료에서 반응합니다. 액상 형태로 제공되며, 고순도 친화 크로마토그래피로 정제되었습니다. 연구용으로만 사용 가능합니다.
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Thermo Fisher Scientific PMCA4 ATPase Polyclonal Antibody
Applications and Tested Dilution
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:1,000–1:4,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1141–1205 of human ATP2B4 (NP_0016753) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 1.95 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804305 |
Product Specific Information
- Immunogen sequence: ELPRTPLLDE EEEENPDKAS KFGTRVLLLD GEVTPYANTN NNAVDCNQVQ LPQSDSSLQS LETSV
- Positive Samples: Mouse brain
- Cellular Location: Cell membrane, Cell projection, Multi-pass membrane protein, cilium, flagellum membrane
Target Information
The calcium pump of the plasma membrane, termed PMCA ATPase, pumps calcium from the cytosol to the extracellular space. This membrane-bound enzyme is related to other ATPases including SERCA ATPase and the sodium/K⁺ pump. Four different genes encode PMCA ATPase, producing 20 isoforms via alternative splicing.
mRNA studies show that gene products 1 and 4 are widely expressed, while products 2 and 3 are tissue-specific. In the pancreas, beta cells express only the 4b isoform, whereas alpha and gamma cells express both 4a and 4b. Different splice variants exhibit distinct affinities for calcium and calmodulin (Cat. # MA3-917 and MA3-918).
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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