Thermo Fisher Scientific RPRD1B Polyclonal Antibody
Thermo Fisher Scientific의 RPRD1B Polyclonal Antibody는 인간, 마우스, 랫트에 반응하며 Western blot, IHC, ELISA에 적합합니다. Rabbit IgG 폴리클로날 항체로, 핵 내 RPRD1B 단백질 검출에 사용됩니다. 고순도 친화 크로마토그래피 정제 제품입니다.
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Applications
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:100–1:200 |
| ELISA | 1 µg/mL |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse, Rat |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing amino acids 80–326 of human RPRD1B (Q9NQG5) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.94 mg/mL |
| Purification | Affinity Chromatography |
| Storage Buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage Conditions | −20°C, Avoid Freeze/Thaw Cycles |
| Shipping Conditions | Wet ice |
| RRID | AB_2804302 |
Product Specific Information
- Positive Samples: MCF7, SKOV3, NCI-H460, Mouse liver, lung, stomach, spleen, Rat liver
- Cellular Location: Nucleus
- Immunogen Sequence:
EFESVLVDAF SHVAREADEG CKKPLERLLN IWQERSVYGG EFIQQLKLSM EDSKSPPPKA TEEKKSLKRT FQQIQEEEDD DYPGSYSPQD PSAGPLLTEE LIKALQDLEN AASGDATVRQ KIASLPQEVQ DVSLLEKITD KEAAERLSKT VDEACLLLAE YNGRLAAELE DRRQLARMLV EYTQNQKDVL SEKEKKLEEY KQKLARVTQV RKELKSHIQS LPDLSLLPNV TGGLAPLPSA GDLFSTD
Target Information
Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of RNA polymerase II subunit POLR2A and participates in CTD dephosphorylation by RPAP2. Acts as a transcriptional regulator enhancing expression of CCND1 and other cell cycle-related genes (CDK2, CDK4, CDK6, cyclin-E). Promotes RNA polymerase II binding to promoter and termination regions, contributing to chromatin loop formation and cell proliferation.
[UniProt]
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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