Thermo Fisher Scientific NMDAR2D Polyclonal Antibody
NMDAR2D 단백질을 인식하는 Rabbit Polyclonal 항체로, Western blot 및 ELISA에 적합합니다. 인간 시료에 반응하며, 고순도의 친화 크로마토그래피로 정제되었습니다. PBS/glycerol buffer에 보관되며, 연구용으로만 사용 가능합니다.
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:500–1:2,000 |
| ELISA | 1 µg/mL |
Product Specifications
| 항목 | 내용 |
|---|---|
| Species Reactivity | Human |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 330–480 of human GRIN2D (NP_0008272) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 3.07 mg/mL |
| Purification | Affinity Chromatography |
| Storage buffer | PBS, pH 7.3, with 50% glycerol |
| Contains | 0.02% sodium azide |
| Storage conditions | -20°C, Avoid Freeze/Thaw Cycles |
| Shipping conditions | Wet ice |
| RRID | AB_2804299 |
Product Specific Information
Immunogen sequence:
GAQALLRDYG FLPELGHDCR AQNRTHRGES LHRYFMNITW DNRDYSFNED GFLVNPSLVV ISLTRDRTWE VVGSWEQQTL RLKYPLWSRY GRFLQPVDDT QHLTVATLEE RPFVIVEPAD PISGTCIRDS VPCRSQLNRT HSPPPDAPRP E
Positive Samples: SH-SY5Y, Mouse liver
Cellular Location: Cell junction, Cell membrane, Multi-pass membrane protein, postsynaptic cell membrane, synapse
Target Information
Glutamate receptors mediate most excitatory neurotransmission in the brain and play important roles in neural plasticity, development, and neurodegeneration. Ionotropic glutamate receptors include NMDA and kainate/AMPA receptors, both containing glutamate-gated, cation-specific ion channels. Kainate/AMPA receptors co-localize with NMDA receptors in many synapses and consist of seven subunits (GluR-1 to -7).
Kainate/AMPA receptors mainly mediate fast excitatory neurotransmission, whereas NMDA receptors show slower Ca²⁺ kinetics and higher Ca²⁺ permeability. NMDA receptors comprise five subunits: epsilon 1–4 and one zeta subunit. The zeta subunit is widely expressed in the brainstem, while epsilon subunits have more limited distribution.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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