Thermo Fisher Scientific ATP6V1C2 Monoclonal Antibody (OTI8H4), TrueMAB

Applications

Western Blot (WB)

• Tested Dilution: 1:2,000

Immunohistochemistry (Paraffin) (IHC (P))

• Tested Dilution: 1:150

Product Specifications

Product Specific Information

For reconstitution, add 100 µL distilled water to achieve a final antibody concentration of about 1 mg/mL.
For conjugation experiments, perform an additional desalting step (Zeba Spin Desalting Columns, 7K MWCO, 0.5 mL, Product #89882).

Target Information

ATP6V1C2 encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles.
V-ATPase dependent organelle acidification is essential for intracellular processes such as:

• Protein sorting
• Zymogen activation
• Receptor-mediated endocytosis
• Synaptic vesicle proton gradient generation

V-ATPase consists of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain includes three A, three B, and two G subunits, as well as C, D, E, F, and H subunits, and contains the ATP catalytic site.
This gene produces alternate transcriptional splice variants encoding different V1 domain C subunit isoforms.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.