Thermo Fisher Scientific Calpain 3 Polyclonal Antibody

Applications

Product Specifications

Product Specific Information

This antibody detects endogenous levels of total CAPN3.

Target Information

Calpain is an intracellular calcium-dependent protease that cleaves cytoskeletal and submembranous proteins, playing a role in cytoskeletal reorganization and muscle protein degradation. It is a heterodimer composed of a small regulatory subunit and one of three large catalytic subunits: calpain 1, calpain 2, and calpain 3.
Calpain 3 (also known as calpain p94) is a muscle-preferred, calcium-activated neutral protease localized to the nucleus. Mutations in the calpain 3 gene are associated with limb-girdle muscular dystrophy type 2A, an autosomal recessive progressive neuromuscular disorder.
Calpastatin regulates calpain by inhibiting its proteolytic activity and membrane binding. Two calpastatin types exist—tissue type and erythrocyte type—resulting from alternative splicing and proteolytic processing.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.