Thermo Fisher Scientific RBM25/RED120 Polyclonal Antibody
Thermo Fisher Scientific의 RBM25/RED120 Polyclonal Antibody는 인간 및 생쥐 반응성을 가지며 Western blot, IHC, IP 등에 사용됩니다. 항원 친화 크로마토그래피로 정제된 비접합 액상 항체로, RNA 결합 단백질 RBM25를 표적합니다. 연구용으로만 사용됩니다.
- 카탈로그번호
- A301068A
- 판매단위
- pk
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Applications and Tested Dilutions
| Application | Tested Dilution |
|---|---|
| Western Blot (WB) | 1:2,000–1:10,000 |
| Immunohistochemistry (IHC) | 1:200–1:1,000 |
| Immunohistochemistry (Paraffin) (IHC (P)) | 1:200–1:1,000 |
| Immunoprecipitation (IP) | 2–5 µg/mg lysate |
Product Specifications
| Specification | Description |
|---|---|
| Species Reactivity | Human, Mouse |
| Host / Isotype | Rabbit / IgG |
| Class | Polyclonal |
| Type | Antibody |
| Immunogen | Region between residue 475 and 525 of Human RNA binding motif protein 25 (Arg/Glu/Asp-rich protein, 120 kDa) |
| Conjugate | Unconjugated |
| Form | Liquid |
| Concentration | 0.20 mg/mL |
| Purification | Antigen affinity chromatography |
| Storage Buffer | TBS, pH 7.0–8.0, with 0.1% BSA |
| Contains | 0.09% sodium azide |
| Storage Conditions | 4°C |
| Shipping Conditions | Wet ice |
Product Specific Information
- Recommended shelf life: 1 year from date of receipt
- Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.
Target Information
RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.
Involved in apoptotic cell death through regulation of BCL2L1 isoform expression.
Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression.
When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5′-splice site selection, whereas depletion causes accumulation of antiapoptotic isoform L.
Promotes BCL2L1 isoform S 5′-ss usage through the 5′-CGGGCA-3′ RNA sequence.
Associates with LUC7L3 to promote U1 snRNP binding to a weak 5′ ss in a 5′-CGGGCA-3′-dependent manner.
Binds to the exonic splicing enhancer 5′-CGGGCA-3′ RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.
Also involved in generation of an abnormal and truncated splice form of SCN5A in heart failure.
For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.
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