Thermo Fisher Scientific RBM25/RED120 Polyclonal Antibody

Applications and Tested Dilutions

Product Specifications

Product Specific Information

• Recommended shelf life: 1 year from date of receipt
• Application Note: For IHC, epitope retrieval with citrate buffer pH 6.0 is recommended for FFPE tissue sections.

Target Information

RNA-binding protein that acts as a regulator of alternative pre-mRNA splicing.
Involved in apoptotic cell death through regulation of BCL2L1 isoform expression.
Modulates the ratio of proapoptotic BCL2L1 isoform S to antiapoptotic BCL2L1 isoform L mRNA expression.
When overexpressed, stimulates proapoptotic BCL2L1 isoform S 5′-splice site selection, whereas depletion causes accumulation of antiapoptotic isoform L.
Promotes BCL2L1 isoform S 5′-ss usage through the 5′-CGGGCA-3′ RNA sequence.
Associates with LUC7L3 to promote U1 snRNP binding to a weak 5′ ss in a 5′-CGGGCA-3′-dependent manner.
Binds to the exonic splicing enhancer 5′-CGGGCA-3′ RNA sequence located within exon 2 of the BCL2L1 pre-mRNA.
Also involved in generation of an abnormal and truncated splice form of SCN5A in heart failure.

For Research Use Only. Not for use in diagnostic procedures. Not for resale without express authorization.